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Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis.

ABSTRACT: The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC₅₀ 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC₅₀ 52 μg/mL. The isolated compounds 1-3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM.

SUBMITTER: Kalenga TM

PROVIDER: S-EPMC9513791 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis.

Kalenga Thobias M TM Mollel Jackson T JT Said Joanna J Orthaber Andreas A Ward Jas S JS Atilaw Yoseph Y Umereweneza Daniel D Ndoile Monica M MM Munissi Joan J E JJE Rissanen Kari K Trybala Edward E Bergström Tomas T Nyandoro Stephen S SS Erdelyi Mate M

Journal of natural products 20220908 9

The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes ...[more]

PMID: 36075014

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