Dynamic reorganization of the cortico-basal ganglia-thalamo-cortical network during task learning.

ABSTRACT: Adaptive behavior is coordinated by neuronal networks that are distributed across multiple brain regions such as in the cortico-basal ganglia-thalamo-cortical (CBGTC) network. Here, we ask how cross-regional interactions within such mesoscale circuits reorganize when an animal learns a new task. We apply multi-fiber photometry to chronically record simultaneous activity in 12 or 48 brain regions of mice trained in a tactile discrimination task. With improving task performance, most regions shift their peak activity from the time of reward-related action to the reward-predicting stimulus. By estimating cross-regional interactions using transfer entropy, we reveal that functional networks encompassing basal ganglia, thalamus, neocortex, and hippocampus grow and stabilize upon learning, espec

SUBMITTER: Sych Y 

PROVIDER: S-EPMC9513804 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature