Hypoxia alters posterior cingulate cortex metabolism during a memory task: A ¹H fMRS study.

ABSTRACT: Environmental hypoxia (fraction of inspired oxygen (F_IO₂) ∼ 0.120) is known to trigger a global increase in cerebral blood flow (CBF). However, regionally, a heterogeneous response is reported, particularly within the posterior cingulate cortex (PCC) where decreased CBF is found after two hours of hypoxic exposure. Furthermore, hypoxia reverses task-evoked BOLD signals within the PCC, and other regions of the default mode network, suggesting a reversal of neurovascular coupling. An alternative explanation is that the neural architecture supporting cognitive tasks is reorganised. Therefore, to confirm if this previous result is neural or vascular in origin, a measure of neural activity that is not haemodynamic-dependant is required. To achieve this, we utilised functio

SUBMITTER: Rogan M 

PROVIDER: S-EPMC9513808 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature