A pyroptosis-associated signature plays a role in prognosis prediction in clear cell renal cell carcinoma.

ABSTRACT:

Background

Approximately 90% of renal malignancies are RCCs (renal cell carcinomas), and the primary subtype in histology is ccRCC (clear cell RCC). In recent years, pyroptosis has been considered a kind of inflammation-related programmed cell death that participates in the invasion, metastasis, and proliferation of tumour cells, thereby influencing tumour prognosis. Nonetheless, the expression level of pyroptosis-associated genes in RCCs and their relationship with prognosis remain obscure.

Results

In our research, 44 regulators of pyroptosis that were differentially expressed between normal kidney and ccRCC tissues were identified. ccRCC cases were categorized into 2 subgroups according to prognostic-related DEGs (differentially expressed genes), and there was a significan

SUBMITTER: Li Z 

PROVIDER: S-EPMC9513884 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature