The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China.

ABSTRACT:

Background

Assessment of immune function is of key importance in recognition of disease or healthy status, which still faces challenge in clinical practice. We conducted a 10-center study to investigate lymphocyte parameters including the number, phenotype and IFN-γ-producing ability, and routine laboratory indicators by using the standard method.

Results

Although the heterogeneity of lymphocyte parameters was widely found, we have established the normal ranges of these parameters by using pooled data which showed no significant difference among centers. Cluster analysis of 35 parameters found 3 interesting clusters which represented different immunological status. Cluster 1 (parameters: IFN-γ⁺CD4⁺ T cell percentage and IFN-γ⁺CD8⁺

SUBMITTER: Liu W 

PROVIDER: S-EPMC9513899 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature