Radiation segmentectomy of hepatic metastases with Y-90 glass microspheres.

ABSTRACT:

Purpose

To evaluate safety and efficacy of radiation segmentectomy (RS) with ⁹⁰Y glass microspheres in patients with limited metastatic liver disease not amenable to resection or percutaneous ablation.

Methods

Patients with ≤ 3 tumors treated with RS from 6/2015 to 12/2017 were included. Target tumor radiation dose was > 190 Gy based on medical internal radiation dose (MIRD) dosimetry. Tumor response, local tumor progression (LTP), LTP-free survival (LTPFS) and disease progression rate in the treated segment were defined using Choi and RECIST 1.1 criteria. Toxicities were evaluated using modified SIR criteria.

Results

Ten patients with 14 tumors underwent 12 RS. Median tumor size was 3 cm (range 1.4-5.6). Median follow-up was 17.8 months (range 1.6-37.3). R

SUBMITTER: Kurilova I 

PROVIDER: S-EPMC9513941 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature