Three out of four published systematic reviews on COVID-19 treatments were not registered and one-third of those registered were published: a meta-research study.

ABSTRACT:

Objectives

The aim of this study is to describe (1) registered and (2) published systematic reviews (SRs) on COVID-19 treatments, and to analyze (3) the proportion of publications among registered SRs and (4) the proportion of registrations among published SRs.

Study design and setting

This meta-research study (CRD42021240423) is part of CEOsys (http://www.covid-evidenz.de/). Two reviewers identified protocols in PROSPERO (registered January 2020 to September 2020) and SRs published as preprint or peer-reviewed article in L·OVE (Living OVerview of the Evidence) COVID-19 (by May 2021). SRs of all types assessing COVID-19 treatments in humans were included.

Results

We included 239 PROSPERO protocols and 346 SRs published in L·OVE. In both samples, the affiliation of the

SUBMITTER: Siemens W 

PROVIDER: S-EPMC9514002 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature