Clinical utility of subclassifying positive surgical margins at radical prostatectomy.

ABSTRACT:

Objective

To determine whether subclassification of positive surgical margins (PSMs) increases predictive ability for biochemical recurrence (BCR) and aids clinical decision-making in patients undergoing radical prostatectomy.

Patients and methods

We studied 2147 patients with pT2 and pT3a prostate cancer with detailed surgical margin parameters and BCR status. We compared a base model, a linear predictor calculated from the Memorial Sloan Kettering Cancer Center postoperative nomogram (prostate-specific antigen, pathological tumour grade and stage), with the addition of surgical margin status to five additional models (base model plus surgical margin subclassifications) to evaluate enhancement in predictive accuracy. Decision curve analysis (DCA) was performed to determine

SUBMITTER: Dason S 

PROVIDER: S-EPMC9514027 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature