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Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of action.

ABSTRACT:

Background

The question of whether the coronavirus genome contain as-yetununderstood genetic component.

Purpose (objective)

Elucidate the novel functions of the discovered tRNA-like base sequence and lead to the development of novel therapeutic agents.

Methods

A novel tRNA-like base sequence was found in the sequences complementary to the genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV. By comparing mutations in the tRNA-like base sequences of these two viruses, it was found that base pairing in the cloverleaf model of SARS-CoV-2 was more robust than that of SARS-CoV.

Results

The results of homology search between a short sequence of the coronavirus tRNA-like base sequence and human genes suggest that the molecule produced by this novel tRNA-like sequence may be involved in the splicing of human messenger RNA.

Conclusions

Experimental molecular evidence of the tRNA-like base sequence discovered in this study is urgently needed.

SUBMITTER: Inokuchi H

PROVIDER: S-EPMC9514165 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of action.

Inokuchi Hachiro H

Genes & genomics 20220927 11

<h4>Background</h4>The question of whether the coronavirus genome contain as-yetununderstood genetic component.<h4>Purpose (objective)</h4>Elucidate the novel functions of the discovered tRNA-like base sequence and lead to the development of novel therapeutic agents.<h4>Methods</h4>A novel tRNA-like base sequence was found in the sequences complementary to the genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV. By comparing mutations in the tRNA-like base sequen ...[more]

PMID: 36166141

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