Variability in response to vitamin D supplementation according to vitamin D metabolism related gene polymorphisms in healthy adults.

ABSTRACT:

Objective

The aim of this study was to determine the influence of polymorphisms in some key gene actors of the vitamin D (vitD) metabolic pathway on supplementation efficacy.

Methods

In total, 245 healthy participants were recruited from occupational medicine service in Sahloul University Hospital with vitD deficiency [25(OH)D ≤ 30 ng/ml]. After giving an informed consent, all participants were asked to complete a generalized questionnaire and to follow a detailed personalized supplementation protocol. Genetic study was performed by PCR-RFLP for 15 single nucleotide polymorphisms (SNPs) belonging to DBP, CYP2R1, CYP27B14, CYP24A1 and VDR genes. Statistical study was carried out with SPSS23.0.

Results

Among the studied SNPs, non-response was significantly associated wi

SUBMITTER: Ammar M 

PROVIDER: S-EPMC9514197 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature