A genome-wide association study identified one variant associated with static spatial working memory in Chinese population.

ABSTRACT: Spatial working memory (SWM) is a kind of memory that temporarily preserves spatial information (the location or order of objects, etc.). Individuals with mental disorders tend to show worse performance in SWM task. This study investigated the genetic basis of two subtypes of SWM, static spatial working memory (SSWM) and dynamic spatial working memory (DSWM) in humans, using quantitative genomic analyses. A total of 451 Chinese students were tested on their magnitudes of SSWM and DSWM. A genome-wide association study (GWAS) was performed. Two SNPs (top SNP: rs80263879, p = 1.6 × 10^-9, gene: epoxide hydrolase 2, EPHX2) reaching genome-wide significance for SSWM were identified. There is a high linkage disequilibrium between these two SNPs. The data of

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9514234 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature