Slowing gait speed precedes cognitive decline by several years.

ABSTRACT:

Introduction

In this longitudinal study, we aimed to examine if slowing gait speed preceded cognitive decline and correlated with brain amyloidosis.

Methods

The sample (n = 287) was derived from the Gothenburg H70 Birth Cohort Studies, with follow-ups between 2000 and 2015. Gait speed was measured by indoor walk, and cognition using the Clinical Dementia Rating (CDR) score. All participants had CDR = 0 at baseline. Some participants had data on cerebrospinal fluid (CSF) amyloid beta (Aβ)_1-42 concentrations at the 2009 examination.

Results

Gait speed for participants who worsened in CDR score during follow-up was slower at most examinations. Baseline gait speed could significantly predict CDR change from baseline to follow-up. Subjects with pathological CSF

SUBMITTER: Skillback T 

PROVIDER: S-EPMC9514316 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature