Transcriptomics of circulating neutrophils in dairy cows with subclinical hypocalcemia.

ABSTRACT: Hypocalcemia is closely associated with inflammatory diseases in dairy cows. Recent research has underscored the key role of calcium in the adaptations of the innate immune system during this period. The main objective in the present study was to compare the transcriptome profiles and analyze differences in the expression of neutrophil (PMNL) immune function-related genes and calcium binding-related genes in hypocalcemic cows. At 2 days postpartum, a concentration >2.10 mmol Ca²⁺/L was used to classify cows as controls (CON), and a concentration <2.00 mmol Ca²⁺/L used to classify cows as low-calcium (LCAL) (n = 8 in each group). A routine medical examination was conducted by the attending veterinarian to ensure there were no other complications and that the blo

SUBMITTER: Zhang B 

PROVIDER: S-EPMC9514324 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature