Protease-activated indocyanine green nanoprobes for intraoperative NIR fluorescence imaging of primary tumors.

ABSTRACT: Tumor-targeted fluorescent probes in the near-infrared spectrum can provide invaluable information about the location and extent of primary and metastatic tumors during intraoperative procedures to ensure no residual tumors are left in the patient's body. Even though the first fluorescence-guided surgery was performed more than 50 years ago, it is still not accepted as a standard of care in part due to the lack of efficient and non-toxic targeted probes approved by regulatory agencies around the world. Herein, we report protease-activated cationic gelatin nanoparticles encapsulating indocyanine green (ICG) for the detection of primary breast tumors in murine models with high tumor-to-background ratios. Upon intravenous administration, these nanoprobes remain optically silent due to the ene

SUBMITTER: Lew B 

PROVIDER: S-EPMC9514568 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature