Review of Hydroxychloroquine Cardiotoxicity: Lessons From the COVID-19 Pandemic.

ABSTRACT:

Purpose of review

The coronavirus disease 2019 (COVID-19) pandemic has popularized the usage of hydroxychloroquine and chloroquine (HCQ/CQ) as treatments for COVID-19. Previously used as anti-malarial and now commonly used in rheumatologic conditions, preliminary in vitro studies have demonstrated these medications also have anti-viral properties. Retinopathy and neuromyopathy are well recognized complications of using these treatments; however, cardiotoxicity is under-recognized. This review will discuss the implications and cardiotoxicity of HCQ/CQ, their mechanisms of action, and their utility in COVID-19.

Recent findings

Early clinical trials demonstrated a modest benefit of HCQ in COVID-19, causing a push for the usage of it. However, further large multi-center randomiz

SUBMITTER: Gagnon LR 

PROVIDER: S-EPMC9514702 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature