Transcriptional and Immune Landscape of Cardiac Sarcoidosis.

ABSTRACT:

Background

Cardiac involvement is an important determinant of mortality among sarcoidosis patients. Although granulomatous inflammation is a hallmark finding in cardiac sarcoidosis, the precise immune cell populations that comprise the granuloma remain unresolved. Furthermore, it is unclear how the cellular and transcriptomic landscape of cardiac sarcoidosis differs from other inflammatory heart diseases.

Methods

We leveraged spatial transcriptomics (GeoMx digital spatial profiler) and single-nucleus RNA sequencing to elucidate the cellular and transcriptional landscape of cardiac sarcoidosis. Using GeoMX digital spatial profiler technology, we compared the transcriptomal profile of CD68⁺ rich immune cell infiltrates in human cardiac sarcoidosis, giant cell myocar

SUBMITTER: Liu J 

PROVIDER: S-EPMC9514756 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature