The characteristics and clinical significance of atypical mitosis in breast cancer.

ABSTRACT: Atypical mitosis is considered a feature of malignancy, however, its significance in breast cancer (BC) remains elusive. Here, we aimed to assess the clinical value of atypical mitoses in BC and to explore their underlying molecular features. Atypical and typical mitotic figures were quantified and correlated with clinicopathological variables in a large cohort of primary BC tissue sections (n = 846) using digitalized hematoxylin and eosin whole-slide images (WSIs). In addition, atypical mitoses were assessed in The Cancer Genome Atlas (TCGA) BC dataset (n = 1032) and were linked to the genetic alterations and pathways. In this study, the median of typical mitoses was 17 per 3 mm² (range 0-120 mitoses), while the median of atypical mitoses was 4 (range 0-103 mitoses). High atypi

SUBMITTER: Lashen A 

PROVIDER: S-EPMC9514994 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature