The role of ion-lipid interactions and lipid packing in transient defects caused by phenolic compounds.

ABSTRACT: The transient disruption of membranes for the passive permeation of ions or small molecules is a complex process relevant to understanding physiological processes and biotechnology applications. Phenolic compounds are widely studied for their antioxidant and antimicrobial properties, and some of these activities are based on the interactions of the phenolic compound with membranes. Ions are ubiquitous in cells and are known to alter the structure of phospholipid bilayers. Yet, ion-lipid interactions are usually ignored when studying the membrane-altering properties of phenolic compounds. This study aims to assess the role of Ca²⁺ ions on the membrane-disrupting activity of two phenolic acids and to highlight the role of local changes in lipid packing in forming transient defects

SUBMITTER: Hossain SI 

PROVIDER: S-EPMC9515000 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature