Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance.

ABSTRACT: Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In the aged brain, senescent cell identities and the mechanisms by which they exert adverse influence are unclear. Here we used high-dimensional molecular profiling, coupled with mechanistic experiments, to study the properties of senescent cells in the aged mouse brain. We show that senescence and inflammatory expression profiles increase with age and are brain region- and sex-specific. p16-positive myeloid cells exhibiting senescent and disease-associated activation signatures, including upregulation of chemoattractant factors, accumulate in the aged mouse brain. Senescent brain myeloid cells promote peripheral immune cell chemotaxis in vitro. Activated resident and infiltrating immune cells increase

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9515187 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature