Tobacco smoking and binge alcohol use are associated with incident venous thromboembolism in an HIV cohort.

ABSTRACT:

Background

People with HIV (PWH) are at increased risk of cardiovascular comorbidities and substance use is a potential predisposing factor. We evaluated associations of tobacco smoking and alcohol use with venous thromboembolism (VTE) in PWH.

Methods

We assessed incident, centrally adjudicated VTE among 12 957 PWH within the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort between January 2009 and December 2018. Using separate Cox proportional hazards models, we evaluated associations of time-updated alcohol and cigarette use with VTE, adjusting for demographic and clinical characteristics. Smoking was evaluated as pack-years and never, former, or current use with current cigarettes per day. Alcohol use was parameterized using categorical and

SUBMITTER: Luu B 

PROVIDER: S-EPMC9515244 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature