The periodic axon membrane skeleton leads to Na nanodomains but does not impact action potentials.

ABSTRACT: Recent work has established that axons have a periodic skeleton structure comprising of azimuthal actin rings connected via longitudinal spectrin tetramer filaments. This structure endows the axon with structural integrity and mechanical stability. Additionally, voltage-gated sodium channels follow the periodicity of the active-spectrin arrangement, spaced ∼190 nm segments apart. The impact of this periodic arrangement of sodium channels on the generation and propagation of action potentials is unknown. To address this question, we simulated an action potential using the Hodgkin-Huxley formalism in a cylindrical compartment, but instead of using a homogeneous distribution of voltage-gated sodium channels in the membrane, we applied the experimentally determined periodic arrangement. We fou

SUBMITTER: Chai Z 

PROVIDER: S-EPMC9515372 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature