Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection.

ABSTRACT:

Background

The majority of those infected by ancestral Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require hospitalisation. Most had a short-lived mild or asymptomatic infection, while others had symptoms that persisted for weeks or months. We hypothesized that the plasma proteome at the time of first infection would reflect differences in the inflammatory response that linked to symptom severity and duration.

Methods

We performed a nested longitudinal case-control study and targeted analysis of the plasma proteome of 156 healthcare workers (HCW) with and without lab confirmed SARS-CoV-2 infection. Targeted proteomic multiple-reaction monitoring analysis of 91 pre-selected proteins was undertaken in unin

SUBMITTER: Captur G 

PROVIDER: S-EPMC9515404 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature