Effectiveness and safety of fibrinolytic therapy in critically ill patients with COVID-19 with ARDS: protocol for a prospective meta-analysis.

ABSTRACT:

Introduction

The use of fibrinolytic therapy has been proposed in severe acute respiratory distress syndrome (ARDS). During the COVID-19 pandemic, anticoagulation has received special attention due to the frequent findings of microthrombi and fibrin deposits in the lungs and other organs. Therefore, the use of fibrinolysis has been regarded as a potential rescue therapy in these patients. In this prospective meta-analysis, we plan to synthesise evidence from ongoing clinical trials and thus assess whether fibrinolytic therapy can improve the ventilation/perfusion ratio in patients with severe COVID-19-caused ARDS as compared with standard of care.

Methods and analysis

This protocol was registered in PROSPERO. All randomised controlled trials and prospective observational tri

SUBMITTER: Kovacs EH 

PROVIDER: S-EPMC9515457 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature