Systematic review of monotherapy with biologicals for children and adults with IgE‐mediated food allergy

ABSTRACT: Abstract

Background

Biological therapies relieve symptoms in allergic inflammatory diseases so we systematically reviewed the evidence about whether biological monotherapy could benefit people with IgE‐mediated food allergy.

Methods

We searched six bibliographic databases from 1946 to 30 September 2021 for randomised and non‐randomised controlled trials about biological monotherapy in people with IgE‐mediated food allergy confirmed by oral food challenge. We used the Grading of Recommendations, Assessment, Development and Evaluation approach to narratively summarise findings from three trials with 118 participants. The studies were too heterogeneous and sparse to conduct meta‐analysis.

Results

We included one randomised trial about etokimab, one about omalizumab

SUBMITTER: de Silva D 

PROVIDER: S-EPMC9515515 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature