The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study.

ABSTRACT: Observational studies have indicated the associations between obesity with bone mineral density (BMD) and fracture but yield inconsistent results. The impact of childhood obesity on bone health in adulthood is even less clear. The present study adopted the Mendelian randomization methods to determine whether the genetically predicted childhood obesity was causally associated with BMD and the risk of fracture. Genetic variants were extracted from genome-wide association studies (GWAS) to identify childhood obesity loci [IEU open GWAS project: childhood obesity (ID: ieu-a-1096)] and single nucleotide polymorphisms (SNPs) as instrumental variables to investigate causality. We used two-sample univariable Mendelian randomization (MR) to estimate causal relationships between childhood obesity on

SUBMITTER: Liang Y 

PROVIDER: S-EPMC9515586 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature