The transcriptome profile of RPE cells by the fullerenol against hydrogen peroxide stress.

ABSTRACT: Age-related macular degeneration (AMD) causes central vision impairment with increased incidence. In the pathogenesis of AMD, reactive oxygen species (ROS) are associated with RPE cell apoptosis. H₂O₂ is an oxidative toxicant and is used to establish the AMD in vitro model. However, the mechanisms of ROS in H₂O₂-induced AMD are still unclear. Fullerenol, a promising antioxidant of nanomaterials, protects RPE cells from ROS attack. In addition to working as a scavenger, little is known about the antioxidant mechanism of fullerenol in RPE cells. In this study, transcriptome sequencing was performed to examine the global changes in mRNA transcripts induced by H₂O₂ in human ARPE-19 cells. Moreover, we comprehensively inve

SUBMITTER: Wu X 

PROVIDER: S-EPMC9515647 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature