Effect of CNTNAP2 polymorphism on receptive language in children with autism spectrum disorder without language developmental delay.

ABSTRACT:

Aim

The receptive language ability of individuals with autism spectrum disorder (ASD) seems to lag behind expressive language ability. Several autism-related genes may influence this developmental delay. Polymorphism of one such gene, namely, the contactin-associated protein-like 2 gene (CNTNAP2), affects receptive language in individuals with language delay. However, the association between CNTNAP2 polymorphism and receptive language in individuals with no language delay remains unclear.

Methods

We included 59 children with ASD and 57 children with typical development in this study and investigated this association using coarse-grained exact matching.

Results

We present the first evidence of an association between CNTNAP2 rs2710102 (A-allele carrier) and reduced rece

SUBMITTER: Shiota Y 

PROVIDER: S-EPMC9515703 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature