Effects of high-fat diet on nutrient metabolism and cognitive functions in young APPKI^{NL-G-F/NL-G-F} mice.

ABSTRACT:

Aim

Type 2 diabetes mellitus (T2DM) is an increased risk factor for Alzheimer's disease (AD); however, the relationship between the 2 conditions is controversial. High-fat diet (HFD) causes cognitive impairment with/without Aβ accumulation in middle-aged or aged transgenic (Tg) and knock-in (KI) AD mouse models, except for metabolic disorders, which commonly occur in all mice types. Alternatively, whether HFD in early life has an impact on nutrient metabolism and neurological phenotypes in young AD mouse models is not known. In the present study, we examined the effects of HFD on young APPKI^{NL-G-F/NL-G-F} mice, one of the novel KI-AD mouse models.

Methods

The mice were categorized by diet into 2 experimental groups, normal diet (ND) and HFD. Four-week-old wild-type

SUBMITTER: Wang W 

PROVIDER: S-EPMC9515707 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature