Interaction between social behavior and paternal age in offspring of the same paternal mice.

ABSTRACT:

Aim

Previous studies reported that advanced paternal age (APA) may increase the risk of autism spectrum disorder (ASD) in offspring. However, effects of APA on behaviors have not been investigated in offspring of the same paternal mice. The present study sought to identify behavioral differences in mouse offspring of the same fathers at different paternal ages.

Methods

We assessed locomotor activity, anxiety-like behavior, and social behavior in male mouse offspring that were born from the same fathers at three different paternal ages (3, 12, and 15 months old).

Results

No differences in locomotor activity or anxiety-like behavior were observed among any of the offspring groups. In the three-chamber test, although the control group (3-month-old paternal age) exhibited

SUBMITTER: Tanaka M 

PROVIDER: S-EPMC9515711 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature