Epstein-Barr Virus and multiple sclerosis in a Spanish cohort: A two-years longitudinal study.

ABSTRACT:

Objectives

1. To analyze the prevalence and levels of anti-EBNA-1 and anti-VCA IgG antibodies of Epstein-Barr virus (EBV) in a Spanish cohort of multiple sclerosis (MS) patients and their interactions with other environmental and genetic risk factors. 2. To analyze the association of the evolution of these antibodies with the clinical response to different disease modifying therapies (DMTs) after two-years of follow-up. 3. To assess their possible correlation with the class II HLA alleles as well as with several SNPs identified in GWAS related to disease susceptibility.

Materials and methods

We recruited 325 MS patients without DMT (serum samples were collected 1-3 months before starting a therapy) and 295 healthy controls (HC). For each patient we also collected serum sampl

SUBMITTER: Dominguez-Mozo MI 

PROVIDER: S-EPMC9515943 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature