MnCO₃-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers.

ABSTRACT: Background: Single imaging modality is still insufficient to evaluate the biological and anatomical structures of tumors with high accuracy and reliability. Generation of non-specific contrast, leading to a low target-to-background signal ratio, results in low imaging resolution and accuracy. Tumor environment-specific activatable multifunctional contrast agents need to maximize the contrast signals, representing a dual imaging-guided photothermal therapy (PTT) at target tumor sites. Methods: Cellular uptake, cytotoxicity assay, and in vitro photothermal conversion efficiency of MnCO₃-mineralized fluorescent polydopamine nanoparticles (MnCO₃-FPNPs) were evaluated using 4T1 breast cancer cells. In vivo dual-modality imaging was performed usi

SUBMITTER: Lee KK 

PROVIDER: S-EPMC9516237 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature