Outcomes of Gene Panel Testing for Sensorineural Hearing Loss in a Diverse Patient Cohort.

ABSTRACT:

Importance

A genetic diagnosis can help elucidate the prognosis of hearing loss, thus significantly affecting management. Previous studies on diagnostic yield of hearing loss genetic tests have been based on largely homogenous study populations.

Objectives

To examine the diagnostic yield of genetic testing in a diverse population of children, accounting for sociodemographic and patient characteristics, and assess whether these diagnoses are associated with subsequent changes in clinical management.

Design, setting, and participants

This retrospective cohort study included 2075 patients seen at the Children's Communications Clinic, of whom 517 completed hearing loss gene panel testing between January 1, 2015, and November 1, 2021, at the University of California, San F

SUBMITTER: Liao EN 

PROVIDER: S-EPMC9516276 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature