Modulating membrane fusion through the design of fusogenic DNA circuits and bilayer composition.

ABSTRACT: Membrane fusion is a ubiquitous phenomenon linked to many biological processes, and represents a crucial step in liposome-based drug delivery strategies. The ability to control, ever more precisely, membrane fusion pathways would thus be highly valuable for next generation nano-medical solutions and, more generally, the design of advanced biomimetic systems such as synthetic cells. In this article, we present fusogenic nanostructures constructed from synthetic DNA which, different from previous solutions, unlock routes for modulating the rate of fusion and making it conditional to the presence of soluble DNA molecules, thus demonstrating how membrane fusion can be controlled through simple DNA-based molecular circuits. We then systematically explore the relationship between lipid-membrane

SUBMITTER: Paez-Perez M 

PROVIDER: S-EPMC9516350 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature