Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial.

ABSTRACT:

Background

Children born extremely preterm disproportionately experience sequelae of preterm birth compared to those born at later gestational ages, including higher prevalence of autism spectrum disorder (ASD) and associated behaviors.

Aim

Explore effects of combined dietary docosahexaenoic acid, eicosapentaenoic acid, gamma-linolenic acid, and oleic acid (omega 3-6-9) on caregiver-reported behavior and sleep in toddlers born at ≤29 weeks' gestation who were exhibiting symptoms commonly seen with ASD.

Study design

90-day randomized (1:1), double blinded, placebo-controlled trial.

Subjects

Thirty-one children aged 18-38 months received omega 3-6-9 (n = 15) or canola oil placebo (n = 16).

Outcome measures

Mixed effects regression analyses followed intent

SUBMITTER: Boone KM 

PROVIDER: S-EPMC9516351 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature