Effects of some anti-diabetic herbal extracts on the insulin-degrading enzyme in human colon cancer Caco-2 cell line.

ABSTRACT:

Objective

Type 2 diabetes mellitus (T2DM) is a condition characterized by insufficient insulin production or insulin resistance. The insulin-degrading enzyme (IDE) is responsible for degrading insulin and is a potential drug target for T2DM treatment. Numerous activities have been proposed for plant extracts, but research on the effects of plant extracts on IDE expression and activity is riddled with drawbacks.

Materials and methods

We investigated the effect of Phaseolus vulgaris, Allium cepa, Portulaca oleracea, Cinnamomum verum, and Citrullus colocynthis extracts on the expression and activity of IDE in the Caco-2 cell line.

Results

Findings of RT-PCR showed that IDE gene expression was reduced following treatment with P. vulgaris, C. colocynthis,<

SUBMITTER: Norouzi M 

PROVIDER: S-EPMC9516401 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature