Seroreduction of syphilis non-treponemal titers during pregnancy for women with and without HIV co-infection.

ABSTRACT:

Objective

To evaluate the effect of HIV co-infection on non-treponemal titers during pregnancy in women with syphilis.

Methods

This is a secondary analysis of pregnant women with syphilis in the prospective, observational Zambian Preterm Birth Prevention Study (ZAPPS). Treponemal (Treponema pallidum particle agglutination) and non-treponemal (rapid plasma reagin; RPR) testing were performed on serum biospecimens, resulting in 47 participants with serologically confirmed syphilis (27 HIV-positive, 20 HIV-negative). The primary outcome, achievement of RPR titer seroreduction during pregnancy, was analyzed by logistic regression. Secondary outcomes included overall titer reduction, seroreduction rate, serologic cure, and adverse pregnancy outcomes.

Results

Seroreduction

SUBMITTER: Webster CM 

PROVIDER: S-EPMC9516483 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature