Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium.

ABSTRACT: Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management avenues. Our current understanding of oral health genomics suggests that dental caries and periodontitis are polygenic diseases, and very large sample sizes and informative phenotypic measures are required to discover signals and adequately map associations across the human genome. In this article, we introduce the second wave of the Gene-Lifestyle Interactions and Dental Endpoints consortium (GLIDE2) and discuss relevant data analytics challenges, opportunities, and applications. In this phase, the consortium comprises a diverse, multiethnic sample of over 700,000 par

SUBMITTER: Divaris K 

PROVIDER: S-EPMC9516613 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature