Marine DNA methylation patterns are associated with microbial community composition and inform virus-host dynamics.

ABSTRACT:

Background

DNA methylation in prokaryotes is involved in many different cellular processes including cell cycle regulation and defense against viruses. To date, most prokaryotic methylation systems have been studied in culturable microorganisms, resulting in a limited understanding of DNA methylation from a microbial ecology perspective. Here, we analyze the distribution patterns of several microbial epigenetics marks in the ocean microbiome through genome-centric metagenomics across all domains of life.

Results

We reconstructed 15,056 viral, 252 prokaryotic, 56 giant viral, and 6 eukaryotic metagenome-assembled genomes from northwest Pacific Ocean seawater samples using short- and long-read sequencing approaches. These metagenome-derived genomes mostly represented novel tax

SUBMITTER: Seong HJ 

PROVIDER: S-EPMC9516812 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature