Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing.

ABSTRACT:

Background

Adrenergic alpha-1 receptor antagonists (alpha-1 antagonists) are frequently used medications in the management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and in the management of therapy-resistant arterial hypertension, two conditions frequently found in older adults. This systematic review aims at presenting a complete overview of evidence over the benefits and risks of alpha-1 antagonist treatment in people ≥ 65 years, and at deriving recommendations for a safe application of alpha-1 antagonists in older adults from the evidence found.

Methods

A comprehensive literature search was performed (last update March 25^th 2022) including multiple databases (Medline/Pubmed, Embase, the Cochrane Library) and using t

SUBMITTER: Mansbart F 

PROVIDER: S-EPMC9516834 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature