Clinical efficacy analysis of mesenchymal stem cell therapy in patients with COVID-19: A systematic review.

ABSTRACT:

Background

Currently, ongoing trials of mesenchymal stem cells (MSC) therapies for coronavirus disease 2019 (COVID-19) have been reported.

Aim

In this study, we investigated whether MSCs have therapeutic efficacy in novel COVID-19 patients.

Methods

Search terms included stem cell, MSC, umbilical cord blood, novel coronavirus, severe acute respiratory syndrome coronavirus-2 and COVID-19, applied to PubMed, the Cochrane Controlled Trials Register, EMBASE and Web of Science.

Results

A total of 13 eligible clinical trials met our inclusion criteria with a total of 548 patients. The analysis showed no significant decrease in C-reactive protein (CRP) levels after stem cell therapy (P = 0.11). A reduction of D-dimer levels was also not observed in patients afte

SUBMITTER: Cao JX 

PROVIDER: S-EPMC9516915 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature