Neural representations of cryo-EM maps and a graph-based interpretation.

ABSTRACT:

Background

Advances in imagery at atomic and near-atomic resolution, such as cryogenic electron microscopy (cryo-EM), have led to an influx of high resolution images of proteins and other macromolecular structures to data banks worldwide. Producing a protein structure from the discrete voxel grid data of cryo-EM maps involves interpolation into the continuous spatial domain. We present a novel data format called the neural cryo-EM map, which is formed from a set of neural networks that accurately parameterize cryo-EM maps and provide native, spatially continuous data for density and gradient. As a case study of this data format, we create graph-based interpretations of high resolution experimental cryo-EM maps.

Results

Normalized cryo-EM map values interpolated using the non

SUBMITTER: Ranno N 

PROVIDER: S-EPMC9517980 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature