Dynamics of acylcarnitines, hypoglycin A, methylenecyclopropylglycine and their metabolites in a Kladruber stallion with atypical myopathy.

ABSTRACT: Equine atypical myopathy (AM also referred to as multiple acyl-CoA dehydrogenases deficiency [MADD]) is thought to be caused by toxins metabolized from hypoglycin A (HGA) and méthylènecyclopropylglycine (MCPrG). HGA is contained in the seeds and seedlings of the sycamore tree (Acer pseudoplatanus); MCPrG has so far only been confirmed in seeds. Among other things, these substances can disrupt the fatty acids β-oxidation pathway with the subsequent accumulation of certain acylcarnitines. The tentative diagnosis is based on anamnesis and clinical signs and can be verified by the detection of elevated creatine kinase activity, specific profile of acylcarnitines and the presence of HGA, MCPrG conjugates and/or their metabolites in peripheral blood and/or urine. Dry blood spots were coll

SUBMITTER: Jahn P 

PROVIDER: S-EPMC9518284 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature