The Association Between Weight Gain, Sex, and Immune Activation Following the Initiation of Antiretroviral Therapy.

ABSTRACT:

Background

Immune activation persists despite suppressive antiretroviral therapy (ART) and may be affected by sex or body composition. We explored these relationships in a subset of participants who initiated ART in two large randomized trials.

Methods

Purposeful sampling selected participants who achieved virologic suppression on ART and either maintained weight within ± 0.5 kg/m2 or gained 2.6-6.4 kg/m2 from baseline to 96 weeks. We measured 7 markers of inflammation and immune activation at weeks 0 and 96. Multivariable linear regression explored associations of weight gain, sex, and pre-ART BMI with pre-ART and changes in biomarker concentrations.

Results

340 participants were selected; median pre-ART age 42 years, CD4+ cell count 273 cells/mm3, HIV-1 RNA 4.7 log1

SUBMITTER: Bares SH 

PROVIDER: S-EPMC9518745 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature