Shared genetics between nonobstructive azoospermia and primary ovarian insufficiency.

ABSTRACT:

Objective

Primary ovarian insufficiency (POI) and Non-obstructive azoospermia (NOA) both represent disease states of early, and often complete, failure of gametogenesis. Because oogenesis and spermatogenesis share the same conserved steps in meiosis I, it is possible that inherited defects in meiosis I could lead to shared causes of both POI and NOA. Currently, known genes that contribute to both POI and NOA are limited. In this review article, we provide a systematic review of genetic mutations in which both POI and NOA phenotypes exist.

Evidence review

A PubMed literature review was conducted from January 1, 2000 through October 2020. We included all studies that demonstrated human cases of POI or NOA due to a specific genetic mutation either within the same family or in s

SUBMITTER: Verrilli L 

PROVIDER: S-EPMC9518791 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature