Diagnostic value of an algorithm for autoimmune epilepsy in a retrospective cohort.

ABSTRACT:

Purpose

This study aims to propose a diagnostic algorithm for autoimmune epilepsy in a retrospective cohort and investigate its clinical utility.

Methods

We reviewed 60 patients with focal epilepsy with a suspected autoimmune etiology according to board-certified neurologists and epileptologists. To assess the involvement of the autoimmune etiology, we used the patients' sera or cerebrospinal fluid (CSF) samples to screen for antineuronal antibodies using rat brain immunohistochemistry. Positive samples were analyzed for known antineuronal antibodies. The algorithm applied to assess the data of all patients consisted of two steps: evaluation of clinical features suggesting autoimmune epilepsy and evaluation using laboratory and imaging findings (abnormal CSF findings, hyperm

SUBMITTER: Sakamoto M 

PROVIDER: S-EPMC9518792 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature