Gene expression profiling identifies candidate biomarkers for new latent tuberculosis infections. A cohort study.

ABSTRACT:

Objective

To determine the gene expression profile in individuals with new latent tuberculosis infection (LTBI), and to compare them with people with active tuberculosis (TB) and those exposed to TB but not infected.

Design

A prospective cohort study. Recruitment and follow-up were conducted between September 2016 to December 2018. Gene expression and data processing and analysis from April 2019 to April 2021.

Setting

Two male Colombian prisons.

Participants

15 new tuberculin skin test (TST) converters (negative TST at baseline that became positive during follow-up), 11 people that continued with a negative TST after two years of follow-up, and 10 people with pulmonary ATB.

Main outcome measures

Gene expression profile using RNA sequencing from PBMC samp

SUBMITTER: Herrera M 

PROVIDER: S-EPMC9518923 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature