Tyk2 is a tumor suppressor in colorectal cancer.

ABSTRACT: Janus kinase Tyk2 is implicated in cancer immune surveillance, but its role in solid tumors is not well defined. We used Tyk2 knockout mice (Tyk2^Δ/Δ) and mice with conditional deletion of Tyk2 in hematopoietic (Tyk2^ΔHem) or intestinal epithelial cells (Tyk2^ΔIEC) to assess their cell type-specific functions in chemically induced colorectal cancer. All Tyk2-deficient mouse models showed a higher tumor burden after AOM-DSS treatment compared to their corresponding wild-type controls (Tyk2^+/+ and Tyk2^fl/fl), demonstrating tumor-suppressive functions of Tyk2 in immune cells and epithelial cancer cells. However, specific deletion of Tyk2 in hematopoietic cells or in intestinal epithelial cells was insufficient to accelerate tumor progression

SUBMITTER: Moritsch S 

PROVIDER: S-EPMC9519006 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature