Gut metagenomic characteristics of ADHD reveal low Bacteroides ovatus-associated host cognitive impairment.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous psychiatric disorder that can have three phenotypical presentations: inattentive (I-ADHD), hyperactive-impulsive (HI-ADHD), and combined (C-ADHD). Environmental factors correlated with the gut microbiota community have been implicated in the development of ADHD. However, whether different ADHD symptomatic presentations are associated with distinct microbiota compositions and whether patients could benefit from the correction of aberrant bacterial colonization are still largely unclear. We carried out metagenomic shotgun analysis with 207 human fecal samples to characterize the gut microbial profiles of patients with ADHD grouped according to their phenotypical presentation. Then, we transplanted the candidate low-abu

SUBMITTER: Li Y 

PROVIDER: S-EPMC9519028 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature