Prognostic and immunotherapeutic significance of mannose receptor C type II in 33 cancers: An integrated analysis.

ABSTRACT: Background: The type 2 mannose receptor C (MRC2) is involved in tumor biological processes and plays a new role in the remodeling of the extracellular matrix turnover. Previous studies have demonstrated MRC2 expression profiling and prognostic relevance in some tumor types. However, the clinical and immunotherapeutic value of MRC2 in pan-cancers remains controversial. Our study aimed to evaluate MRC2 expression pattern, clinical characteristics and prognostic significance in 33 cancers, explore the relationship between MRC2 and immune-related characteristics, and assess the prediction of MRC2 for the immunotherapeutic response. Methods: Transcriptional and clinical data of 33 cancers were downloaded from The Cancer Genome Atlas database (TCGA) database and two independent imm

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC9519056 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature