Excessive fructose intake inhibits skeletal development in adolescent rats via gut microbiota and energy metabolism.

ABSTRACT: Excessive fructose intake from desserts and beverages may influence bone development among adolescents. The gut microbiota (GM) and energy metabolism play important roles in bone development. In this study, 40 female adolescent rats were randomly assigned to the control group, the fructose group with two concentrations, and the glucose group as the positive control group. After 10 weeks, serum glucose and lipids were detected by means of an automatic analyzer, and the bone microstructure was analyzed by Micro-CT. Then, the GM was determined via 16S rRNA sequencing analysis, and energy metabolism was detected by measuring serum carbohydrate metabolites. At last, bone metabolism markers were measured via ELISA kits. The results showed that excessive fructose intake could increa

SUBMITTER: Gao T 

PROVIDER: S-EPMC9519145 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature